Congratulations to the lab for publishing its first paper in the journal Cartilage. In this paper, we investigated the role of sirtuin 5 (Sirt5) in regulating protein malonylation (MaK) and cellular metabolism in chondrocytes under obesity-related conditions. This study provides the first evidence that Sirt5 broadly regulates chondrocyte metabolism. We observed changes in SIRT5 and MaK levels in cartilage with obesity and joint injury, suggesting that the Sirt5-MaK pathway may contribute to altered chondrocyte metabolism that occurs during OA development. Paper link
